An arrangement and a method for studying the dissolution of particles in the air/blood barrier of the respiratory tract. A device for simulating the interaction of particles (203) delivered to the air/blood barrier of the respiratory tract comprises: a perfusion chamber (101) adapted to receive and deliver a flow of perfusion fluid; a semi permeable membrane (205) coated on one side with a barrier layer (204) adapted to interact with the particles; and a first sheet formed organ (202) having a surface distributed with the particles. The membrane (205) is arranged to be a fluid contact with the perfusion fluid, while the first sheet formed organ (202) is arranged to contact the barrier layer (204) of the membrane (205), in order to simulate the dissolution of the particles (203) in the air/blood barrier when perfusion fluid flows through the perfusion chamber (101), along the membrane (205). Providing a flow of perfusion fluid along the membrane simulates more accurately the natural process of the air/blood barrier.