Invention Grant
US08349308B2 Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
失效
用于递送多核苷酸的改性聚合物，其制备方法及其使用方法
- Patent Title: Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
- Patent Title (中): 用于递送多核苷酸的改性聚合物，其制备方法及其使用方法
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Application No.: US13073815Application Date: 2011-03-28
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Publication No.: US08349308B2Publication Date: 2013-01-08
- Inventor: Aleksandr Yurkovetskiy , Mao Yin , Timothy B. Lowinger , Carolina B. Cabral , Charles E. Hammond , Cheri A. Stevenson
- Applicant: Aleksandr Yurkovetskiy , Mao Yin , Timothy B. Lowinger , Carolina B. Cabral , Charles E. Hammond , Cheri A. Stevenson
- Applicant Address: US MA Cambridge
- Assignee: Mersana Therapeutics, Inc.
- Current Assignee: Mersana Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Ivor R. Elrifi; Heidi A. Erlacher
- Main IPC: A61K31/74
- IPC: A61K31/74 ; A61K47/48 ; C07H21/04 ; C12N15/11
Abstract:
A polynucleotide delivery vehicle comprising a modified polymer is provided herein, the modified polymer having the following formula: in which W1, W2, W3, W4, W5, W6, Z1, Z2, Z3, Z4, Z5, Z9, R1, R2, R3, R4, R5, n1, n2, n3, n4, n5, and n6 are defined herein. Also disclosed are methods of delivering a polynucleotide to the cytoplasm of a selected tissue type or cell type and methods of reducing expression of a gene in a cell or a subject in need thereof with the modified polymer.
Public/Granted literature
- US20110243880A1 MODIFIED POLYMERS FOR DELIVERY OF POLYNUCLEOTIDES, METHOD OF MANUFACTURE, AND METHODS OF USE THEREOF Public/Granted day:2011-10-06
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