Invention Grant
- Patent Title: Mutant interleukin-2 (IL-2) polypeptides
- Patent Title (中): 突变型白细胞介素-2（IL-2）多肽
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Application No.: US13088045Application Date: 2011-04-15
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Publication No.: US08349311B2Publication Date: 2013-01-08
- Inventor: Karl Dane Wittrup , Balaji M. Rao , Douglas A. Lauffenburger
- Applicant: Karl Dane Wittrup , Balaji M. Rao , Douglas A. Lauffenburger
- Applicant Address: US MA Cambridge
- Assignee: Massachusetts Institute of Technology
- Current Assignee: Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Amy E. Mandragouras, Esq.; Christopher L. Frank
- Main IPC: A61K38/20
- IPC: A61K38/20 ; C07K14/55
Abstract:
The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2Rα). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2α using yeast surface display to generate mutants with increased affinity for IL-2Rα.
Public/Granted literature
- US20110306752A1 MUTANT INTERLEUKIN-2 (IL-2) POLYPEPTIDES Public/Granted day:2011-12-15
Information query
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