Invention Grant
- Patent Title: Immediate release pharmaceutical granule compositions and a continuous process for making them
- Patent Title (中): 立即释放药物颗粒组合物和制备它们的连续方法
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Application No.: US12815715Application Date: 2010-06-15
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Publication No.: US08349366B2Publication Date: 2013-01-08
- Inventor: Jean Paul Remon , Chris Vervaet
- Applicant: Jean Paul Remon , Chris Vervaet
- Applicant Address: BE Ghent
- Assignee: Universiteit Gent
- Current Assignee: Universiteit Gent
- Current Assignee Address: BE Ghent
- Agency: Clark & Elbing LLP
- Priority: GB0205253.8 20020306
- Main IPC: A61K9/14
- IPC: A61K9/14

Abstract:
A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from above about 20% to 50% by weight of the composition, said pharmaceutical or veterinary granule composition providing a drug release of at least 70% within 10 minutes in water, (ii) a first excipient being a maltodextrin representing from 40% by weight to 85% by weight of said composition, (iii) a wetting amount of a second excipient being a polyethylene glycol having a weight number molecular weight between 300 and 5,000, said second excipient comprising a solid fraction and a liquid fraction, and representing from 15% to 40% by weight of said composition, and optionally one or more pharma-ceutically acceptable fillers selected from the group consisting of hydrocolloids, glidants, lubricants, surfactants and diluents, wherein the weight ratio of said first excipient (ii) to said second excipient (iii) is in a range from 1:1 to 5:1.
Public/Granted literature
- US20110027377A1 IMMEDIATE RELEASE PHARMACEUTICAL GRANULE COMPOSITIONS AND A CONTINUOUS PROCESS FOR MAKING THEM Public/Granted day:2011-02-03
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