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US08349367B2 Freeze-dried plasma formats for the trauma care field 失效
用于创伤护理领域的冷冻干燥血浆格式

  • Patent Title: Freeze-dried plasma formats for the trauma care field
  • Patent Title (中): 用于创伤护理领域的冷冻干燥血浆格式
  • Application No.: US12681866
    Application Date: 2008-10-14
  • Publication No.: US08349367B2
    Publication Date: 2013-01-08
  • Inventor: Irina B. Bakaltcheva
  • Applicant: Irina B. Bakaltcheva
  • Agency: Remenick PLLC
  • International Application: PCT/US2008/079859 WO 20081014
  • International Announcement: WO2009/049318 WO 20090416
  • Main IPC: A61K35/16
  • IPC: A61K35/16
Freeze-dried plasma formats for the trauma care field
Abstract:
Disclosed are freeze-dried plasma formats specifically designed for the trauma care field. Blood plasma is subjected to a glucose removal step, a protein fraction up-concentration step and addition of stabilizers prior to freeze-drying. Preferable stabilizers are glutamine dipeptides, glutamine and glycine. The glutamine based formulation is added direct to plasma and serves three main purposes: 1) Increases stability of plasma proteins and stabilizes pH in freeze-dried state; 2) Increases stability of plasma proteins against Gamma Irradiation and thus allows for the application of a terminal sterilization step; 3) Introduces supplements beneficial to the trauma patient.
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