Invention Grant
- Patent Title: Method for evaluating blood-neural barrier permeability
- Patent Title (中): 评估血液神经屏障渗透性的方法
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Application No.: US12766391Application Date: 2010-04-23
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Publication No.: US08349577B2Publication Date: 2013-01-08
- Inventor: Khalid Iqbal , Sonia Chalbot , Inge Grundke-Iqbal
- Applicant: Khalid Iqbal , Sonia Chalbot , Inge Grundke-Iqbal
- Applicant Address: US NY Menands
- Assignee: Research Foundation For Mental Hygiene, Inc.
- Current Assignee: Research Foundation For Mental Hygiene, Inc.
- Current Assignee Address: US NY Menands
- Agency: Bond Schoeneck & King, PLLC
- Agent David L. Nocilly
- Main IPC: C12Q1/34
- IPC: C12Q1/34
Abstract:
A system and method for evaluating blood-neural barrier permeability. Phospholipid liposomes are labeled with a fluorescent phospholipase A2 substrate and exposed to cerebrospinal fluid. The change in fluorescence is monitored to determine PLA2 activity. The PLA2 activity is used to evaluate the permeability and function of the blood-neural barrier.
Public/Granted literature
- US20100273196A1 System and Method for Evaluating Blood-Neural Barrier Permeability Public/Granted day:2010-10-28
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