Invention Grant
- Patent Title: Commensal strain of E. coli encoding an HIV GP41 protein
- Patent Title (中): 编码HIV GP41蛋白的大肠杆菌共生菌株
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Application No.: US11710512Application Date: 2007-02-26
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Publication No.: US08349586B1Publication Date: 2013-01-08
- Inventor: Dean Hamer
- Applicant: Dean Hamer
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Sheridan Ross P.C.
- Main IPC: C12P1/00
- IPC: C12P1/00 ; C12P21/06
Abstract:
The present invention relates, e.g., to a commensal bacterium which can colonize the genitourinary and/or gastrointestinal mucosa, and which, under suitable conditions, secretes a heterologous antimicrobial polypeptide, wherein the secreted antimicrobial polypeptide is effective to inhibit infectivity by, or a pathogenic activity of, a pathogen. In a most preferred embodiment, the antimicrobial polypeptide inhibits HIV infection (e.g., fusion) and/or pathogenesis. Also described are preventive or therapeutic compositions comprising the commensal bacteria, and methods to inhibit infectivity and/or pathogenesis, using the bacteria.
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