Invention Grant
- Patent Title: Lentiviral vectors for the preparation of immunotherapeutical compositions
- Patent Title (中): 用于制备免疫治疗组合物的慢病毒载体
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Application No.: US13104380Application Date: 2011-05-10
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Publication No.: US08349606B2Publication Date: 2013-01-08
- Inventor: Pierre Charneau , Hüseyin Firat , Véronique Zennou
- Applicant: Pierre Charneau , Hüseyin Firat , Véronique Zennou
- Applicant Address: FR Paris FR Paris FR Paris
- Assignee: Institut Pasteur,Institut National de la Santé et de la Recherche Médicale,Centre National de la Recherche Scientifique
- Current Assignee: Institut Pasteur,Institut National de la Santé et de la Recherche Médicale,Centre National de la Recherche Scientifique
- Current Assignee Address: FR Paris FR Paris FR Paris
- Agency: Law Office of Salvatore Arrigo and Scott Lee, LLP
- Priority: EP99402492 19991011
- Main IPC: C12N15/00
- IPC: C12N15/00 ; A61K39/12 ; C12Q1/70
Abstract:
The invention relates to an immunogenic composition comprising a recombinant vector characterized in that it comprises a polynucleotide comprising the cis-acting central initiation region (cPPT) and the cis-acting termination region (CTS), these regions being of retroviral or retroviral-like origin, said vector comprising in addition a defined nucleotide sequence (transgene or sequence of interest) and regulatory signals of retrotranscription, expression and encapsidation of retroviral or retroviral-like origin, wherein the composition is capable of inducing or of stimulating a cell-mediated response for instance a CTL (Cytotoxic T Lymphocytes) response or a CD4 response, against one or several epitopes encoded by the transgene sequence present in the vector.
Public/Granted literature
- US20110250650A1 LENTIVIRAL VECTORS FOR THE PREPARATION OF IMMUNOTHERAPEUTICAL COMPOSITIONS Public/Granted day:2011-10-13
Information query
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