Invention Grant
US08349844B2 Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists
失效
取代的吡唑并[1,5-A]嘧啶作为代谢型谷氨酸拮抗剂
![Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists](/docs/US/2013-01-08/US08349844B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists
- Patent Title (中): 取代的吡唑并[1,5-A]嘧啶作为代谢型谷氨酸拮抗剂
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Application No.: US13283640Application Date: 2011-10-28
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Publication No.: US08349844B2Publication Date: 2013-01-08
- Inventor: Silvia Gatti McArthur , Erwin Goetschi , Juergen Wichmann , Thomas Johannes Woltering
- Applicant: Silvia Gatti McArthur , Erwin Goetschi , Juergen Wichmann , Thomas Johannes Woltering
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP05108910 20050927
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; C07D471/04 ; A61P25/28 ; A61P25/16 ; A61K31/437
![Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists](/abs-image/US/2013/01/08/US08349844B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.
Public/Granted literature
- US20120041002A1 SUBSTITUTED PYRAZOLO [1,5-A] PYRIMIDINES AS METABOTROPIC GLUTAMATE ANTAGONISTS Public/Granted day:2012-02-16
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