发明授权
US08349844B2 Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists
失效
取代的吡唑并[1,5-A]嘧啶作为代谢型谷氨酸拮抗剂
![Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists](/docs/US/2013-01-08/US08349844B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists
- 专利标题（中）： 取代的吡唑并[1,5-A]嘧啶作为代谢型谷氨酸拮抗剂
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申请号： US13283640申请日： 2011-10-28
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公开(公告)号： US08349844B2公开(公告)日： 2013-01-08
- 发明人: Silvia Gatti McArthur , Erwin Goetschi , Juergen Wichmann , Thomas Johannes Woltering
- 申请人： Silvia Gatti McArthur , Erwin Goetschi , Juergen Wichmann , Thomas Johannes Woltering
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 优先权： EP05108910 20050927
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/519 ; C07D471/04 ; A61P25/28 ; A61P25/16 ; A61K31/437
![Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists](/abs-image/US/2013/01/08/US08349844B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.