Invention Grant
- Patent Title: Inhibitors of janus kinases
- Patent Title (中): 痛风激酶抑制剂
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Application No.: US12677375Application Date: 2008-09-08
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Publication No.: US08349865B2Publication Date: 2013-01-08
- Inventor: Tony Siu , Jonathan Young , Michael Altman , Alan Northrup , Matthew Katcher , Ellalahewage Sathyajith Kumarasinghe , Ekaterina Kozina , Scott Peterson , Matthew Childers
- Applicant: Tony Siu , Jonathan Young , Michael Altman , Alan Northrup , Matthew Katcher , Ellalahewage Sathyajith Kumarasinghe , Ekaterina Kozina , Scott Peterson , Matthew Childers
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Laura M. Ginkel; David A. Muthard
- International Application: PCT/US2008/010507 WO 20080908
- International Announcement: WO2009/035575 WO 20090319
- Main IPC: C07D471/06
- IPC: C07D471/06 ; A61K31/4375
Abstract:
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
Public/Granted literature
- US20100197634A1 INHIBITORS OF JANUS KINASES Public/Granted day:2010-08-05
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