Invention Grant
- Patent Title: Dual-acting antihypertensive agents
- Patent Title (中): 双作用抗高血压药
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Application No.: US13531057Application Date: 2012-06-22
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Publication No.: US08349875B2Publication Date: 2013-01-08
- Inventor: Paul Allegretti , Seok-Ki Choi , Roland Gendron , Paul Fatheree , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- Applicant: Paul Allegretti , Seok-Ki Choi , Roland Gendron , Paul Fatheree , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A01N43/40
- IPC: A01N43/40 ; A61K31/44
Abstract:
The invention is directed to compounds having the formula: wherein: Ar, r, Y, Z, Q, W, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20120264752A1 DUAL-ACTING ANTIHYPERTENSIVE AGENTS Public/Granted day:2012-10-18
Information query
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