Invention Grant
- Patent Title: 4-trimethylammonio-butyrates as CPT2 inhibitors
- Patent Title (中): 4-三甲基铵丁酸酯作为CPT2抑制剂
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Application No.: US12430941Application Date: 2009-04-28
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Publication No.: US08349893B2Publication Date: 2013-01-08
- Inventor: Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Patrizio Mattei
- Applicant: Mirjana Andjelkovic , Simona M. Ceccarelli , Odile Chomienne , Patrizio Mattei
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Gene J. Yao
- Priority: EP08155318 20080429
- Main IPC: A61K31/205
- IPC: A61K31/205 ; C07C229/04 ; A61P3/10
Abstract:
This invention relates to novel 4-trimethylammoniobutyrates of the formula wherein A1, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments.
Public/Granted literature
- US20090270500A1 4-TRIMETHYLAMMONIO-BUTYRATES AS CPT2 INHIBITORS Public/Granted day:2009-10-29
Information query
