Invention Grant
US08349910B2 Aldehyde tags, uses thereof in site-specific protein modification
有权
醛标签，其在位点特异性蛋白质修饰中的用途
- Patent Title: Aldehyde tags, uses thereof in site-specific protein modification
- Patent Title (中): 醛标签，其在位点特异性蛋白质修饰中的用途
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Application No.: US13163574Application Date: 2011-06-17
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Publication No.: US08349910B2Publication Date: 2013-01-08
- Inventor: Isaac S. Carrico , Brian L. Carlson , Peng Wu , Carolyn Ruth Bertozzi
- Applicant: Isaac S. Carrico , Brian L. Carlson , Peng Wu , Carolyn Ruth Bertozzi
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Bozicevic, Field & Francis LLP
- Agent Carol L. Francis
- Main IPC: A61L33/00
- IPC: A61L33/00 ; C07K1/00 ; C12N15/00
Abstract:
The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
Public/Granted literature
- US20110250704A1 Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification Public/Granted day:2011-10-13
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