Invention Grant
- Patent Title: Anti-alpha5/beta1 antibody
- Patent Title (中): 抗α5/β1抗体
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Application No.: US13171289Application Date: 2011-06-28
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Publication No.: US08350010B2Publication Date: 2013-01-08
- Inventor: Anan Chuntharapai , Gregory D. Plowman , Marc Tessier-Lavigne , Yan Wu , Weilan Ye
- Applicant: Anan Chuntharapai , Gregory D. Plowman , Marc Tessier-Lavigne , Yan Wu , Weilan Ye
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Morrison & Foerster LLP
- Main IPC: C07K16/18
- IPC: C07K16/18
Abstract:
The present invention relates to the use of VEGF antagonists and alpha5beta1 antagonists for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to use of a VEGFR agonists and alpha5beta1 agonists to promote angiogenesis and vascular permeability. The present invention also relates to new anti-alpha5beta1 antibodies, compositions and kits comprising them and methods of making and using them.
Public/Granted literature
- US20120195908A1 COMBINATORIAL THERAPY Public/Granted day:2012-08-02
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