Invention Grant
- Patent Title: Antibodies to ErbB2
- Patent Title (中): ErbB2抗体
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Application No.: US12376196Application Date: 2007-08-02
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Publication No.: US08350011B2Publication Date: 2013-01-08
- Inventor: Susan Ann Cartlidge , Jianying Dong , Mark Hickinson , Ian Foltz , Jaspal Singh Kang
- Applicant: Susan Ann Cartlidge , Jianying Dong , Mark Hickinson , Ian Foltz , Jaspal Singh Kang
- Applicant Address: GB Cambridge
- Assignee: MedImmune Limited
- Current Assignee: MedImmune Limited
- Current Assignee Address: GB Cambridge
- Agency: MedImmune Limited
- International Application: PCT/US2007/075078 WO 20070802
- International Announcement: WO2008/019290 WO 20080214
- Main IPC: C07K16/30
- IPC: C07K16/30 ; A61K39/395

Abstract:
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to ErbB2, preferably human ErbB2. In another embodiment, the antibodies or antigen-binding portions thereof inhibit ErbB2. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins or portions thereof derived from human anti-ErbB2 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-ErbB2 antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
Public/Granted literature
- US20100158926A1 ANTIBODIES TO ERBB2 Public/Granted day:2010-06-24
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