Invention Grant
US08350012B2 Inverse agonist monoclonal antibody that suppresses thyrotropin receptor constitutive activity
有权
抑制促甲状腺激素受体结构活性的反向激动剂单克隆抗体
- Patent Title: Inverse agonist monoclonal antibody that suppresses thyrotropin receptor constitutive activity
- Patent Title (中): 抑制促甲状腺激素受体结构活性的反向激动剂单克隆抗体
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Application No.: US12519513Application Date: 2008-01-24
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Publication No.: US08350012B2Publication Date: 2013-01-08
- Inventor: Basil Rapoport , Sandra McLachlan , Chun-Rong Chen
- Applicant: Basil Rapoport , Sandra McLachlan , Chun-Rong Chen
- Applicant Address: US CA Los Angeles
- Assignee: Cedars-Sinai Medical Center
- Current Assignee: Cedars-Sinai Medical Center
- Current Assignee Address: US CA Los Angeles
- Agency: Nixon Peabody LLP
- Agent Linda B. Huber
- International Application: PCT/US2008/051866 WO 20080124
- International Announcement: WO2008/091981 WO 20080731
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K16/00
Abstract:
This invention describes monoclonal antibodies that suppress thyrotropin receptor constitutive activity and methods of using the antibodies to treat thyroid related diseases; particularly hyperthyroidism and thyroid cancer.
Public/Granted literature
- US20110014200A1 MONOCLONAL ANTIBODY THAT SUPPRESSES THYROTROPIN RECEPTOR CONSTITUTIVE ACTIVITY Public/Granted day:2011-01-20
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