Invention Grant
US08350019B2 Recombinant Plasmodium falciparum merozoite surface proteins 4 and 5 and their use
失效
重组恶性疟原虫裂殖子表面蛋白4和5及其用途
- Patent Title: Recombinant Plasmodium falciparum merozoite surface proteins 4 and 5 and their use
- Patent Title (中): 重组恶性疟原虫裂殖子表面蛋白4和5及其用途
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Application No.: US12084240Application Date: 2006-11-23
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Publication No.: US08350019B2Publication Date: 2013-01-08
- Inventor: Shirley Longacre , Hannah Polson , Ronald Perraut , Farida Nato
- Applicant: Shirley Longacre , Hannah Polson , Ronald Perraut , Farida Nato
- Applicant Address: FR Paris FR Paris
- Assignee: Institut Pasteur,Centre National de la Recherche Scientifique
- Current Assignee: Institut Pasteur,Centre National de la Recherche Scientifique
- Current Assignee Address: FR Paris FR Paris
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner L.L.P.
- International Application: PCT/IB2006/003967 WO 20061123
- International Announcement: WO2007/060550 WO 20070531
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C12N15/00 ; C12N15/09 ; C12P21/02 ; C12P19/00 ; A61K39/00
Abstract:
Accordingly, the invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was surprisingly found that the recombinant polypeptides contain an EGF-like domain at the C-terminus that is properly folded in the polypeptide.
Public/Granted literature
- US20100092520A1 Recombinant Plasmodium Falciparum Merozoite Surface Proteins 4 and 5 and Their Use Public/Granted day:2010-04-15
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