Invention Grant
- Patent Title: Method for the stereoselective synthesis of phosphorus compounds
- Patent Title (中): 磷化合物的立体选择性合成方法
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Application No.: US12935073Application Date: 2009-04-03
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Publication No.: US08350022B2Publication Date: 2013-01-08
- Inventor: Chris Meier , Jens O. Thomann
- Applicant: Chris Meier , Jens O. Thomann
- Applicant Address: DE Hamburg
- Assignee: Universitaet Hamburg
- Current Assignee: Universitaet Hamburg
- Current Assignee Address: DE Hamburg
- Agency: Patent Central LLC
- Agent Stephen A. Pendorf
- Priority: DE102008017500 20080404
- International Application: PCT/DE2009/000437 WO 20090403
- International Announcement: WO2009/121347 WO 20091008
- Main IPC: C07H21/00
- IPC: C07H21/00
Abstract:
The present invention relates to a method for stereoselective synthesis of phosphorus compounds, whereby in the first reaction step a chiral auxiliary on the phosphorus atom of phosphoryl chloride, thiophosphoryl chloride or phosphorus trichloride is covalently bonded, the product from the first reaction step is reacted in the following step with an alcohol, thiol, or amine as the nucleophile in the presence of a base, and in the last step the chiral auxiliary is displaced from the product of the following step by a nucleophile.
Public/Granted literature
- US20110028705A1 METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF PHOSPHORUS COMPOUNDS Public/Granted day:2011-02-03
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