Invention Grant
- Patent Title: Dual-acting pyrazole antihypertensive agents
- Patent Title (中): 双效吡唑抗高血压药
-
Application No.: US13346237Application Date: 2012-01-09
-
Publication No.: US08350027B2Publication Date: 2013-01-08
- Inventor: Brooke Blair , Paul R. Fatheree , Melissa Fleury , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Michael Wilson
- Applicant: Brooke Blair , Paul R. Fatheree , Melissa Fleury , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Michael Wilson
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: C07D413/14
- IPC: C07D413/14 ; C07D401/14 ; C07D259/00 ; C07D271/06 ; C07D231/10
Abstract:
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20120259113A1 DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS Public/Granted day:2012-10-11
Information query
