Invention Grant
- Patent Title: Processes for the synthesis of levocetirizine and intermediates for use therein
- Patent Title (中): 用于合成左西替利嗪及其中间体的方法
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Application No.: US12993011Application Date: 2009-06-02
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Publication No.: US08350031B2Publication Date: 2013-01-08
- Inventor: Dharmaraj Ramachandra Rao , Rajendra Narayanrao Kankan , Maruti Ghagare , Sandip Vasant Chikhalikar
- Applicant: Dharmaraj Ramachandra Rao , Rajendra Narayanrao Kankan , Maruti Ghagare , Sandip Vasant Chikhalikar
- Applicant Address: IN Mumbai
- Assignee: CIPLA Limited
- Current Assignee: CIPLA Limited
- Current Assignee Address: IN Mumbai
- Agency: Conley Rose, P.C.
- Agent Rodney B. Carroll
- Priority: IN1173/MUM/2008 20080602
- International Application: PCT/GB2009/001385 WO 20090602
- International Announcement: WO2009/147389 WO 20091210
- Main IPC: C07D241/04
- IPC: C07D241/04
Abstract:
The present invention provides a compound of formula (IV) wherein R is Cl, Br, NO2, OH or OR′, and R′ is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (−)-1-[(4-chlorophenyl)-phenylmethyl]piperazine, an intermediate useful in the synthesis of levocetirizine. The present invention also provides compounds (II) and (III) which are useful in the synthesis of compound (IV).
Public/Granted literature
- US20110184174A1 Processes for the Synthesis of Levocetirizine and Intermediates for Use Therein Public/Granted day:2011-07-28
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