Invention Grant
US08350040B2 Process for preparing (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2- methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol
有权
制备（α，βR）-6-溴-α-[2-（二甲基氨基）乙基] -2-甲氧基-α-1-萘基-β-苯基-3-喹啉乙醇的方法
![Process for preparing (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2- methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol](/docs/US/2013-01-08/US08350040B2/abs.jpg.600x600.jpg)
- Patent Title: Process for preparing (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2- methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol
- Patent Title (中): 制备（α，βR）-6-溴-α-[2-（二甲基氨基）乙基] -2-甲氧基-α-1-萘基-β-苯基-3-喹啉乙醇的方法
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Application No.: US13225647Application Date: 2011-09-06
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Publication No.: US08350040B2Publication Date: 2013-01-08
- Inventor: Frank Ralf Porstmann , Stefan Horns , Thomas Bader
- Applicant: Frank Ralf Porstmann , Stefan Horns , Thomas Bader
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica N.V.
- Current Assignee: Janssen Pharmaceutica N.V.
- Current Assignee Address: BE Beerse
- Agent Thomas J. Dodd
- Priority: EP05104482 20050525
- Main IPC: C07D215/00
- IPC: C07D215/00 ; C07F9/02
![Process for preparing (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2- methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol](/abs-image/US/2013/01/08/US08350040B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a process for isolating (αS,βR)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent.
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