Invention Grant
US08350045B2 Process for preparation of E-isomer of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidino prop-1-ene and acid addition salts thereof
有权
1-（4-甲基苯基）-1-（2-吡啶基）-3-吡咯烷基丙-1-烯及其酸加成盐的E-异构体的制备方法
- Patent Title: Process for preparation of E-isomer of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidino prop-1-ene and acid addition salts thereof
- Patent Title (中): 1-（4-甲基苯基）-1-（2-吡啶基）-3-吡咯烷基丙-1-烯及其酸加成盐的E-异构体的制备方法
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Application No.: US12808516Application Date: 2008-12-16
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Publication No.: US08350045B2Publication Date: 2013-01-08
- Inventor: Rajender Pershad Gupta , Veerabhadra Swamy Hiremath , Raghavendra Arekal Vasanna , Vasantha Gowda Nekkilar
- Applicant: Rajender Pershad Gupta , Veerabhadra Swamy Hiremath , Raghavendra Arekal Vasanna , Vasantha Gowda Nekkilar
- Applicant Address: IN
- Assignee: Hikal Limited
- Current Assignee: Hikal Limited
- Current Assignee Address: IN
- Agency: Choate Hall & Stewart LLP
- Agent Andrea L. C. Robidoux; Xiaodong Li
- Priority: IN3003/CHE/2007 20071217
- International Application: PCT/IN2008/000839 WO 20081216
- International Announcement: WO2009/084035 WO 20090709
- Main IPC: C07D401/02
- IPC: C07D401/02
Abstract:
A process for preparation of E-isomer of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene of Formula-I, and acid addition salts thereof, said process comprising; dehydrating 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinopropan-1-ol of Formula III followed by adding a base solution to obtain a mixture of E and Z isomers of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene, and washing said mixture of E and Z isomers of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene with water to dissolve Z isomer and to obtain E-isomer of 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene of Formula I, which is substantially free from Z isomer.
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