Invention Grant
- Patent Title: Method for producing 3-methyl-2-thiophenecarboxylic acid
- Patent Title (中): 3-甲基-2-噻吩羧酸的制备方法
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Application No.: US13000937Application Date: 2009-06-25
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Publication No.: US08350057B2Publication Date: 2013-01-08
- Inventor: Takayoshi Ando , Norio Adachi , Akihiro Isogai
- Applicant: Takayoshi Ando , Norio Adachi , Akihiro Isogai
- Applicant Address: JP Osaka-shi
- Assignee: Ishihara Sangyo Kaisha, Ltd.
- Current Assignee: Ishihara Sangyo Kaisha, Ltd.
- Current Assignee Address: JP Osaka-shi
- Agency: Oblon, Spivik, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2008-167970 20080626
- International Application: PCT/JP2009/061661 WO 20090625
- International Announcement: WO2009/157525 WO 20091230
- Main IPC: C07D333/40
- IPC: C07D333/40
Abstract:
A method for producing 3-methyl-2-thiophenecarboxylic acid is provided.A method for producing 3-methyl-2-thiophenecarboxylic acid, which comprises reacting a compound represented by the formula (I): (wherein X is a chlorine atom or a bromine atom) with magnesium in the presence of an alkyl halide to give a Grignard reagent represented by the formula (II): (wherein X is the same as defined above), reacting the Grignard reagent of the formula (II) with carbon dioxide, and acidifying the reaction product.
Public/Granted literature
- US20110112311A1 METHOD FOR PRODUCING 3-METHYL-2-THIOPHENECARBOXYLIC ACID Public/Granted day:2011-05-12
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