Invention Grant
US08350065B2 5,6-dimethyl xanthone-4-acetic acid derivatives and method of preparing the same
有权
5,6-二甲基呫吨酮-4-乙酸衍生物及其制备方法
- Patent Title: 5,6-dimethyl xanthone-4-acetic acid derivatives and method of preparing the same
- Patent Title (中): 5,6-二甲基呫吨酮-4-乙酸衍生物及其制备方法
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Application No.: US12581184Application Date: 2009-10-19
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Publication No.: US08350065B2Publication Date: 2013-01-08
- Inventor: Wei Li , Guofan Xie , Jianzhong Zhou , Bo Yang , Zhiqiang Qian , Yan Chen , Haiming Geng , Jianming Zhou , Lu Huang
- Applicant: Wei Li , Guofan Xie , Jianzhong Zhou , Bo Yang , Zhiqiang Qian , Yan Chen , Haiming Geng , Jianming Zhou , Lu Huang
- Applicant Address: CN Wuhan
- Assignee: Grand Pharma (China) Co., Ltd.
- Current Assignee: Grand Pharma (China) Co., Ltd.
- Current Assignee Address: CN Wuhan
- Agency: Matthias Scholl P.C.
- Agent Matthias Scholl
- Priority: WO2008/071161 20080602
- Main IPC: C07D311/80
- IPC: C07D311/80 ; C07D311/82 ; C07D311/86
Abstract:
A method of preparation of 5,6-dimethylxanthone-4-acetic acid (DMXAA) and derivatives thereof. The derivatives are represented by formula (I), wherein R represents totally 1 to 2 substitutes at 1, 2, 3, 7, and 8 position selected from a lower alkyl, halogen, CF3, CN, NO2, NH2, CH2COOH, OR2, OH, NHSO2R2, SR2, CH2CONHR2 or NHR2, and R2 represents a lower alkyl, or a lower alkyl having OH, NH2, or OCH3. The invention further provides a pharmaceutical composition having such derivatives used as excellent antitumor and antibacterial agents.
Public/Granted literature
- US20100099754A1 5,6-DIMETHYL XANTHONE-4-ACETIC ACID DERIVATIVES AND METHOD OF PREPARING THE SAME Public/Granted day:2010-04-22
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