Invention Grant
US08350089B2 Yield-efficient process for the production of highly pure 2-methyl-1,4-naphthoquinone and its derivatives
失效
用于生产高纯度2-甲基-1,4-萘醌及其衍生物的生产效率高的方法
- Patent Title: Yield-efficient process for the production of highly pure 2-methyl-1,4-naphthoquinone and its derivatives
- Patent Title (中): 用于生产高纯度2-甲基-1,4-萘醌及其衍生物的生产效率高的方法
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Application No.: US13004629Application Date: 2011-01-11
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Publication No.: US08350089B2Publication Date: 2013-01-08
- Inventor: Kamyab Amouzegar , Behzad Mahdavi , Charles Didier , Alexander Lieb , Mathieu Langevin
- Applicant: Kamyab Amouzegar , Behzad Mahdavi , Charles Didier , Alexander Lieb , Mathieu Langevin
- Applicant Address: CH Basel
- Assignee: Lonza Ltd.
- Current Assignee: Lonza Ltd.
- Current Assignee Address: CH Basel
- Agency: Hoffmann & Baron, LLP
- Priority: EP10000252 20100113
- Main IPC: C07C45/00
- IPC: C07C45/00 ; C07C50/18

Abstract:
The present invention discloses a process for the production of 2-methyl-1,4-naphthoquinone and its bisulfite adducts, comprising the following steps: a) oxidizing 2-methyl-naphthalene (2-MNA) to achieve an organic phase containing 2-methyl-naphthoquinone (2-MNQ) and 6-methyl-naphthoquinone (6-MNQ); b) subjecting said organic phase to treatment with an aqueous solution of a bisulfite salt to extract preferentially the 6-MNQ isomer from the organic phase; c) separating said organic phase from the aqueous phase; d) subjecting the organic phase of process step c) to a second bisulfidation step with an aqueous solution of a bisulfite salt, resulting in an organic phase containing 2-MNA and trace amounts of 2-MNQ and an aqueous phase containing 2-MSB and trace amounts of 6-MSB; e) optionally removing interfering bisulfite ions from the aqueous phase of process step c); f) raising the pH of the aqueous phase from step c) or e) to higher than 8.5 in the presence of a solvent resulting in an organic phase containing 2-MNQ; g) combining the organic phase from step f) with the organic phase being treated in the process step d); h) recycling the organic phase from step d) back to step a) to be used as solvent for the oxidation reaction of 2-MNA.
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