Described herein is a method and apparatus to wake-up analog bias signals with minimum delay. The apparatus comprises a first logic unit operable to adjust a signal level of a gated bias signal via a first predetermined signal in response to a power-down event; a comparator operable to compare the gated bias signal with an un-gated bias signal, and operable to generate an output signal indicating the comparison result; and a self-timed logic unit coupled to the comparator and operable to generate a wake-up signal in response to an end of the power-down event and the output signal.