Systems and methods for safe handling of information handling resources are provided. In some embodiments, a method is provided. The method may include detecting occurrence of a power down sequence and in response to detecting of the power down sequence, controlling operation of a cooling fan coupled to information handling resources based at least on a first criteria of a predetermined policy. The method may include receiving a signal from a sensor, the signal indicating a thermal property of a particular information handling resource coupled to the sensor. The method may include determining if the thermal property satisfies a second criteria of the predetermined policy, the second criteria comprising a safe temperature range for handling the particular information handling resource. If the thermal property meets the second criteria, the method may provide an alert via an indicator to a user indicating the particular information handling resource is safe for handling.