Some demonstrative embodiments include devices, systems and/or methods of managing power saving mechanisms of wireless communication devices. For example, a wireless communication unit may relay communications between a wireless communication device and a base station, wherein the wireless communication unit is to manage a power-saving mechanism of the wireless communication device by scheduling one or more power-save periods for the wireless communication device, and transmitting to the wireless communication device a power-save message indicating the one or more power-save periods. Other embodiments are described and claimed.