An engine control system includes a power supply module, a measurement module, and a calibration module. The power supply module disables power supplied to N components of an engine when M cylinders of the engine are deactivated, wherein M and N are integers greater than or equal to one. The measurement module measures outputs of the N engine components. The calibration module calibrates the measurement module based on unpowered measurements from one or more of the N engine components during a period after the power supplied to the N components is disabled.