发明授权
- 专利标题: Solid dispersion preparation
- 专利标题(中): 固体分散体制备
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申请号: US11736834申请日: 2007-04-18
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公开(公告)号: US08354122B2公开(公告)日: 2013-01-15
- 发明人: Takafumi Hoshino , Fumie Kusaki , Ikuo Fukui
- 申请人: Takafumi Hoshino , Fumie Kusaki , Ikuo Fukui
- 申请人地址: JP Tokyo
- 专利权人: Shin-Etsu Chemical Co., Ltd.
- 当前专利权人: Shin-Etsu Chemical Co., Ltd.
- 当前专利权人地址: JP Tokyo
- 代理机构: Roberts Mlotkowski Safran & Cole, P.C.
- 代理商 David S. Safran
- 优先权: JP2006-116272 20060420; JP2007-087957 20070329
- 主分类号: A61K9/20
- IPC分类号: A61K9/20
摘要:
Provided are a granule or a tablet of a solid dispersion that allows a drug in a preparation to be rapidly dissolved without impairing the dissolution of the solid dispersion, and a method for producing the same. More specifically, provided are a granule of a solid dispersion comprising a poorly soluble drug, a water-soluble polymer, an excipient and a disintegrator, wherein a content of the water-soluble polymer is 1 to 10% by weight and a content of the disintegrator is 15 to 50% by weight; a tablet of a solid dispersion comprising a poorly soluble drug, a water-soluble polymer, an excipient and a disintegrator, wherein a content of the water-soluble polymer is 1 to 5% by weight and a content of the disintegrator is 15 to 50% by weight; and a method for producing a granule or tablet of a solid dispersion comprising spraying a water-soluble polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a mixed powder of an excipient and a disintegrator, and granulating and drying a resultant.
公开/授权文献
- US20070248681A1 SOLID DISPERSION PREPARATION 公开/授权日:2007-10-25
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