发明授权
- 专利标题： Neurotransmitter sensors and methods of using the same
- 专利标题（中）： 神经递质传感器及其使用方法
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申请号： US12823796申请日： 2010-06-25
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公开(公告)号： US08354250B2公开(公告)日： 2013-01-15
- 发明人: Sakiko Okumoto , Loren L. Looger , Wolf B. Frommer
- 申请人： Sakiko Okumoto , Loren L. Looger , Wolf B. Frommer
- 申请人地址： US DC Washington
- 专利权人： Carnegie Institution of Washington
- 当前专利权人： Carnegie Institution of Washington
- 当前专利权人地址： US DC Washington
- 代理机构： Morgan, Lewis & Bockius LLP
- 主分类号： C07K19/00
- IPC分类号： C07K19/00 ; C12N15/62 ; G01N33/567
摘要：
Neurotransmitter biosensors are disclosed, including YbeJ-based glutamate binding biosensors, comprising a neurotransmitter binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon binding neurotransmitter. Such biosensors are useful for the detection of neurotransmitter concentrations in vivo and in culture.
公开/授权文献
- US20110289609A1 Neurotransmitter Sensors and Methods of Using the Same 公开/授权日：2011-11-24
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