Invention Grant
- Patent Title: Hemifumarate of a pyrazole derivative
- Patent Title (中): 吡唑衍生物的半富马酸盐
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Application No.: US12988273Application Date: 2009-04-13
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Publication No.: US08354382B2Publication Date: 2013-01-15
- Inventor: Hideki Takeuchi , Eiji Tsuru
- Applicant: Hideki Takeuchi , Eiji Tsuru
- Applicant Address: JP Nagano
- Assignee: Kissei Pharmaceutical Co., Ltd.
- Current Assignee: Kissei Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Nagano
- Agency: Sughrue Mion, PLLC
- Priority: JP2008-106582 20080416
- International Application: PCT/JP2009/057439 WO 20090413
- International Announcement: WO2009/128421 WO 20091022
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; C07G3/00 ; C07H15/00 ; C07H17/00 ; C07H17/02 ; C07H23/00
Abstract:
The present invention provides a novel form of 3-(3-{4-[3-(β-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)-2,2-dimethylpropionamide with improved storage stability. Since 3-(3-{4-[3-(β-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}-propylamino)-2,2-dimethylpropionamide hemifumarate dihydrate has extremely excellent storage stability, it is useful as a drug substance. Furthermore, it shows an extremely good crystalline property and can be purified by a convenient method, and therefore is suitable for the industrial preparation.
Public/Granted literature
- US20110034679A1 HEMIFUMARATE OF A PYRAZOLE DERIVATIVE Public/Granted day:2011-02-10
Information query
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