Invention Grant
US08354413B2 Quinolin-4-one and 4-oxodihydrocinnoline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP)
失效
喹啉-4-酮和4-氧代二氢噌啉衍生物作为聚（ADP-核糖）聚合酶（PARP）的抑制剂
- Patent Title: Quinolin-4-one and 4-oxodihydrocinnoline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP)
- Patent Title (中): 喹啉-4-酮和4-氧代二氢噌啉衍生物作为聚（ADP-核糖）聚合酶（PARP）的抑制剂
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Application No.: US12673555Application Date: 2008-08-21
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Publication No.: US08354413B2Publication Date: 2013-01-15
- Inventor: Philip Jones , Olaf Kinzel , Uwe Koch , Jesus Maria Ontoria Ontoria , Giovanna Pescatore , Rita Scarpelli , Caterina Torrisi
- Applicant: Philip Jones , Olaf Kinzel , Uwe Koch , Jesus Maria Ontoria Ontoria , Giovanna Pescatore , Rita Scarpelli , Caterina Torrisi
- Applicant Address: IT Rome
- Assignee: Istituto di Ricerche di Biologia Molecolare P. Angeletti, S.R.L.
- Current Assignee: Istituto di Ricerche di Biologia Molecolare P. Angeletti, S.R.L.
- Current Assignee Address: IT Rome
- Agent Yong Zhao; David A. Muthard; Matthew A. Leff
- Priority: GB0716532.7 20070824
- International Application: PCT/GB2008/050731 WO 20080821
- International Announcement: WO2009/027730 WO 20090305
- Main IPC: A61K31/497
- IPC: A61K31/497 ; A61K31/47 ; A61K31/535 ; A01N43/42 ; C07D215/30 ; C07D215/00 ; C07D215/12 ; C07D215/14
Abstract:
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
Public/Granted literature
- US20110207720A1 QUINOLIN-4-ONE AND 4-OXODIHYRDOCINNOLINE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) Public/Granted day:2011-08-25
Information query
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