发明授权
US08354545B2 3,4-substituted pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease
有权
用于治疗阿尔茨海默病的3,4-取代吡咯烷β-分泌酶抑制剂
- 专利标题： 3,4-substituted pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease
- 专利标题（中）： 用于治疗阿尔茨海默病的3,4-取代吡咯烷β-分泌酶抑制剂
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申请号： US12747605申请日： 2008-12-10
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公开(公告)号： US08354545B2公开(公告)日： 2013-01-15
- 发明人: Shawn J. Stachel , Thomas Steele , Alessia Petrocchi
- 申请人： Shawn J. Stachel , Thomas Steele , Alessia Petrocchi
- 申请人地址： US NJ Rahway IT Rome
- 专利权人： Merck, Sharp & Dohme, Corp.,Istituto di Ricerche di Biologia Molecolare P Angeletti SPA
- 当前专利权人： Merck, Sharp & Dohme, Corp.,Istituto di Ricerche di Biologia Molecolare P Angeletti SPA
- 当前专利权人地址： US NJ Rahway IT Rome
- 代理商 Keith D. MacMillan; Gerard M. Devlin
- 国际申请： PCT/US2008/013550 WO 20081210
- 国际公布： WO2009/078932 WO 20090625
- 主分类号： C07D401/06
- IPC分类号： C07D401/06 ; C07D207/06 ; C07D403/14 ; C07D413/06 ; A61K31/535 ; A61K31/445 ; A61K31/415 ; A61K31/4025
摘要：
The present invention is directed to 3,4-substituted pyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.