A system and process for analyzing multidimensional data characterizing a least a portion of a subject is described. An input module accepts at least one multidimensional dataset which is derived from any of several types of data sources. A registration module accepts the dataset from the input module and registers the dataset from the input module to a selected anatomical model to provide a registered dataset. A processing module is coupled to the registration module and uses this in determining a core region and associated core region information, and computes threshold characteristics of the registered dataset. A segmentation module accepts the registered dataset and the core region information from the processing module, and segments the registered dataset to provide a segmented description of an organ from the registered dataset and core region information, where the segmented, registered dataset describes characteristics of the organ of the subject.