An anti-debugger comprises spatially and temporally separate detection and response portions. In an example configuration, the anti-debugger is implemented into a game system for detecting and responding to a debugger attached to a game application. The detection portion is implemented on one thread of the system and the response portion is implemented on another thread of the system. When a debugger is detected, a message indicative of the detection is provided to a thread interface. The thread interface provides the message to the response portion. After a period of time has elapsed, the response portion disables the functionality of the game application, such as by halting the game execution and/or obfuscating game performance.