发明授权
- 专利标题： Pyridines
- 专利标题（中）： 吡啶类
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申请号： US12772250申请日： 2010-05-03
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公开(公告)号： US08357703B2公开(公告)日： 2013-01-22
- 发明人: Bernd Buettelmann , Roland Jakob-Roetne , Henner Knust , Matthew C. Lucas , Andrew Thomas
- 申请人： Bernd Buettelmann , Roland Jakob-Roetne , Henner Knust , Matthew C. Lucas , Andrew Thomas
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 优先权： EP09159631 20090507
- 主分类号： A61K31/4427
- IPC分类号： A61K31/4427 ; C07D413/12
摘要：
The present invention is concerned with novel isoxazoles of formula I wherein X, R1, R2, R3 and R4 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A α5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula I, pharmaceutical compositions containing them and their use as therapeutics.
公开/授权文献
- US20100286117A1 PYRIDINES 公开/授权日：2010-11-11