A trouble diagnosis device and method for an NOx sensor for determining abnormality of an NOx sensor used in an exhaust gas purification system. The device can perform a trouble diagnosis without forcedly creating a diagnosis mode during operation of an internal combustion engine and without deterioration of drivability or fuel consumption. The device detects the time-lapse variation of the exhaust NOx flow rate suitable for diagnosis in a normal operation mode and determines whether the NOx sensor responds with following this variation.