Invention Grant
US08362002B2 Azetidines as MEK inhibitors for the treatment of proliferative diseases
有权
Azetidines作为治疗增殖性疾病的MEK抑制剂
- Patent Title: Azetidines as MEK inhibitors for the treatment of proliferative diseases
- Patent Title (中): Azetidines作为治疗增殖性疾病的MEK抑制剂
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Application No.: US13048832Application Date: 2011-03-15
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Publication No.: US08362002B2Publication Date: 2013-01-29
- Inventor: Naing Aay , Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Kimo Curtis , Steven Charles DeFina , Larisa Dubenko , Anagha Abhijit Joshi , Abigail R. Kennedy , Angie Inyoung Kim , Elena S. Koltun , Jean-Claire Limun Manalo , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang
- Applicant: Naing Aay , Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Kimo Curtis , Steven Charles DeFina , Larisa Dubenko , Anagha Abhijit Joshi , Abigail R. Kennedy , Angie Inyoung Kim , Elena S. Koltun , Jean-Claire Limun Manalo , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang
- Applicant Address: US CA San Francisco
- Assignee: Exelixis, Inc.
- Current Assignee: Exelixis, Inc.
- Current Assignee Address: US CA San Francisco
- Agency: Honigman Miller Schwartz & Cohn LLP
- Agent Heidi M. Berven; Jonathan P. O'Brien
- Main IPC: A61K31/397
- IPC: A61K31/397 ; A61K31/50 ; A61K31/505 ; A61K31/4523 ; A61K31/4178
Abstract:
Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
Public/Granted literature
- US20110263558A1 Azetidines as MEK Inhibitors for the Treatment of Proliferative Diseases Public/Granted day:2011-10-27
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