Invention Grant
- Patent Title: Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals
- Patent Title (中): 酰氨基取代的稠环戊烷羧酸衍生物及其作为药物的用途
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Application No.: US12939650Application Date: 2010-11-04
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Publication No.: US08362073B2Publication Date: 2013-01-29
- Inventor: Matthias Schaefer , Josef Pernerstorfer , Dieter Kadereit , Hartmut Strobel , Werngard Czechtizky , L. Charlie Chen , Alena Safarova , Aleksandra Weichsel , Marcel Patek
- Applicant: Matthias Schaefer , Josef Pernerstorfer , Dieter Kadereit , Hartmut Strobel , Werngard Czechtizky , L. Charlie Chen , Alena Safarova , Aleksandra Weichsel , Marcel Patek
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agent Jiang Lin
- Priority: EP08290427 20080505
- Main IPC: A61K31/166
- IPC: A61K31/166 ; C07C231/02
Abstract:
The present invention relates to compounds of the formula I, wherein A, Y, Z, R3 to R6, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
Public/Granted literature
- US20110152290A1 ACYLAMINO-SUBSTITUTED FUSED CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS Public/Granted day:2011-06-23
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