发明授权
- 专利标题： Pyridinone antagonists of alpha-4 integrins
- 专利标题（中）： α-4整联蛋白的吡啶酮拮抗剂
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申请号： US12768680申请日： 2010-04-27
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公开(公告)号： US08367836B2公开(公告)日： 2013-02-05
- 发明人: Ying-zi Xu , Shendong Yuan , David Wone , Andrei Konradi
- 申请人： Ying-zi Xu , Shendong Yuan , David Wone , Andrei Konradi
- 申请人地址： US CA South San Francisco
- 专利权人： Elan Pharmaceuticals, Inc.
- 当前专利权人： Elan Pharmaceuticals, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： Foley & Lardner LLP
- 主分类号： C07D413/12
- IPC分类号： C07D413/12 ; C07D401/12 ; C07D213/02 ; A61K31/4412
摘要：
The present invention provides compounds that are alpha4 integrin antagonists having a structure according to the following formula: or a tautomer, mixture of tautomers, salt or solvate thereof, wherein Cy, ring A, m, n, p, R1, R2, R3, R4, R5 and R6 are defined in the specification. The invention further provides pharmaceutical compositions including the compounds of the invention as well as methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various conditions and disorders, such as Crohn's disease and ulcerative colitis.
公开/授权文献
- US20110009407A1 PYRIDINONE ANTAGONISTS OF ALPHA-4 INTEGRINS 公开/授权日：2011-01-13