An electronic circuit on a semiconductor substrate having isolated multiple gate field effect transistor circuit blocks is disclosed. In some embodiments, an electronic circuit has a substrate having a buried oxide insulating region. A MuGFET device may be formed above the buried oxide region and coupled to a first source of reference potential. A semiconductor device may be formed above the substrate and coupled to a second source of reference potential. A coupling network may be formed to couple the MuGFET device to the semiconductor device.