An interference suppression method is provided. A method includes the following steps: determining, by a Femtocell, a set of Femtocells which generate interference with said Femtocell based on information measured by and feedbacked from subscribers which are served by said Femtocell, and delivering the cell IDs of all Femtocells in said set to a Femtocell gateway; establishing, by the Femtocell gateway, a relationship graph on interference among Femtocells according to information delivered from the Femtocells, and clustering the Femtocells based on said relationship graph; determining the range influenced by each Femtocell cluster; allocating resources to the Femtocells in each isolated cluster or in the range influenced by each cluster. It may ensure liable communications of Femtocell subscribers as possible, and/or may maximize spectrum efficiency and system capacity of the Femtocell layer as possible.