发明授权
- 专利标题： Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
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申请号： US12835663申请日： 2010-07-13
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公开(公告)号： US08372881B2公开(公告)日： 2013-02-12
- 发明人: Noa Zerangue , Bernd Jandeleit , Yunxiao Li , Mark A. Gallop
- 申请人： Noa Zerangue , Bernd Jandeleit , Yunxiao Li , Mark A. Gallop
- 申请人地址： US CA Santa Clara
- 专利权人： XenoPort, Inc.
- 当前专利权人： XenoPort, Inc.
- 当前专利权人地址： US CA Santa Clara
- 代理机构： Kilpatrick Townsend & Stockton LLP
- 主分类号： A61K31/27
- IPC分类号： A61K31/27 ; C07C229/46
摘要：
Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl)-cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof to treat or prevent various diseases or disorders are disclosed. Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof suitable for oral and topical administration and for administration using sustained release dosage forms are also disclosed.
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