The present disclosure relates generally to a system and method for superposition coding and interference cancellation in a multiple input multiple output (MIMO) system. In one example, the method includes demultiplexing a signal of a user into at least first and second signal portions and demultiplexing a signal of another user into at least third and fourth signal portions. Superposition coding is performed on the first and third signal portions to form a first composite signal and performed on the second and fourth signal portions to form a second composite signal. The first composite signal is transmitted via at least one antenna of a MIMO system and the second composite signal is transmitted via at least another antenna of the MIMO system.