发明授权
- 专利标题： Methods of making Efavirens and intermediates thereof
- 专利标题（中）： 依法韦仑及其中间体的制备方法
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申请号： US13330381申请日： 2011-12-19
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公开(公告)号： US08378143B2公开(公告)日： 2013-02-19
- 发明人: Bo Chen , Zhi-Xian Wang , Yutao Xue , Lihong Liu , Hao Chen
- 申请人： Bo Chen , Zhi-Xian Wang , Yutao Xue , Lihong Liu , Hao Chen
- 申请人地址： CA Brantford
- 专利权人： Apotex Pharmachem Inc.
- 当前专利权人： Apotex Pharmachem Inc.
- 当前专利权人地址： CA Brantford
- 主分类号： C07C233/54
- IPC分类号： C07C233/54
摘要：
The present invention provides a process for the preparation of Efavirenz. A compound of Formula 1: may be prepared by a process comprising cyclizing, in the presence of a first base, a compound of Formula 5 with a haloformate of Formula 6. Other processes are also provided as well as novel compounds prepared by and used in such processes.
公开/授权文献
- US20120095249A1 METHODS OF MAKING EFAVIRENS AND INTERMEDIATES THEREOF 公开/授权日：2012-04-19
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