A hand pulling drive mechanism includes a hand drive device and a shaft connected with the hand drive device. The mechanism further includes a gear pair, a rotation propelling device connected with the shaft, and an eccentric pulling device including a shaft pin placed on the shaft and a torsion jacket pivotally connected to the shaft and rotated relative to the shaft pin. The gear pair includes a drive gear sleeved on the shaft for switching, and a follower gear secured to a motor shaft. The rotation propelling device is connected with the drive gear. The torsion jacket and the drive gear pull the torsion jacket through eccentric rotation of the shaft pin when the shaft is rotated, so that the drive gear moves in an axial direction and the follower drive engages with and disengages from the drive gear.