发明授权
US08383581B2 Short-chain peptides as parathyroid hormone (PTH) receptor agonist
有权
短链肽作为甲状旁腺激素(PTH)受体激动剂
- 专利标题: Short-chain peptides as parathyroid hormone (PTH) receptor agonist
- 专利标题(中): 短链肽作为甲状旁腺激素(PTH)受体激动剂
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申请号: US13259706申请日: 2010-04-26
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公开(公告)号: US08383581B2公开(公告)日: 2013-02-26
- 发明人: Rajesh Bahekar , Mukul R. Jain , Pankaj R. Patel
- 申请人: Rajesh Bahekar , Mukul R. Jain , Pankaj R. Patel
- 申请人地址: IN Ahmedabad
- 专利权人: Cadila Healthcare Limited
- 当前专利权人: Cadila Healthcare Limited
- 当前专利权人地址: IN Ahmedabad
- 代理机构: Ladas & Parry LLP
- 优先权: IN1095/MUM/2009 20090424; IN225/MUM/2010 20100128
- 国际申请: PCT/IN2010/000264 WO 20100426
- 国际公布: WO2010/128521 WO 20101111
- 主分类号: A61K38/29
- IPC分类号: A61K38/29
摘要:
The present invention provides novel short-chain peptides, which primarily act as parathyroid hormone (PTH/PTH-1) receptor agonist. These short-chain peptides exhibit increased stability to proteolytic cleavage. Most of short-chain peptides were found to be stable in rat plasma up to 24 hours (in vitro), showed increased stability against GIT enzymes such as pepsin and acidic stomach pH and also against liver microsomes (in vitro). Due to increased metabolic stability, other than parenteral route of administration, some of the short-chain peptides can also be delivered by oral routes of administration, for the treatment/prevention of hypoparathyroidism and diseases characterized by bone mass reduction, such as osteoporosis, postmenopausal osteoporosis and for stimulating bone repair. A-Z1-Z2-Z3-Z4-Z5-Z6-Z7-Z8-Z9-Z10-Z11-Z12-Z13-Z14-Z15-B
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