发明授权
- 专利标题： Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof
- 专利标题（中）： 取代的四氢吡喃螺吡咯烷酮和哌啶酮，其制备和治疗用途
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申请号： US13483503申请日： 2012-05-30
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公开(公告)号： US08383814B2公开(公告)日： 2013-02-26
- 发明人: Zhongli Gao , Ryan Hartung , David Stefany
- 申请人： Zhongli Gao , Ryan Hartung , David Stefany
- 申请人地址： FR Paris
- 专利权人： Sanofi
- 当前专利权人： Sanofi
- 当前专利权人地址： FR Paris
- 代理商 Kelly L. Bender
- 优先权： FR0955909 20090828
- 主分类号： C07D491/107
- IPC分类号： C07D491/107 ; C07D401/04 ; C07D401/14 ; C07D401/02
摘要：
The present disclosure relates to a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I): wherein R1, R2, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefore are disclosed.